There is also a record that in 1774, an English farmer B. GEST during an extensive outbreak of smallpox in the vicinity of Dorchester taken from a sick cow smallpox scabs and instilled this material to my wife and two small children. On the site of inoculation for smallpox having characteristic inflamed areas, and even Mrs. GEST fever, which forced to call a doctor. Neighbors resented "cruel" and "inhuman" farmer. However, subsequent events have shown that he was right. When an outbreak of smallpox, his wife and children, who were often in contact with patients, do not become infected, and previously was indignant farmers were victims of the disease. In 1791 the Prussian a similar procedure done Holstein farmer P. Plett. He defended his family from smallpox, instilling them pounded material cowpox scabs.